Oct 4 |
Phthalocyanine for COVID-19: real-time meta analysis of 4 studies | |
| Statistically significant lower risk is seen for ICU admission, hospitalization, recovery, and viral clearance. 3 studies from 3 independent teams (all from the same country) show significant improvements. Meta analysis using the most ser.. | ||
Feb 19 |
et al., Current Oral Health Reports, doi:10.1007/s40496-024-00368-1 | Antiviral Mechanism and Clinical Benefits of Mouthwash Active Against SARS-CoV-2 |
| Review of antiviral mechanisms and clinical benefits of mouthwashes for SARS-CoV-2, including chlorhexidine (CHX), cetylpyridinium chloride (CPC), ethyl lauroyl arginate (ELA), hydrogen peroxide (HP), povidone-iodine (PVP-I), and anionic.. | ||
Jun 23 2023 |
et al., German Medical Science GMS Publishing House, doi:10.3205/000321 | Effect of phthalocyanine oral and nasal antiseptic solutions on the infectivity of SARS-CoV-2 in patients with COVID-19: a randomized controlled trial |
| 51% improved viral clearance (p=0.008). RCT 75 patients in Brazil, showing significantly lower viral load with phthalocyanine mouthwash and nasal spray. The combination was more effective than mouthwash alone. | ||
Jan 28 2022 |
et al., Frontiers in Drug Delivery, doi:10.3389/fddev.2023.1164671 (date from preprint) | On a model-based approach to improve intranasal spray targeting for respiratory viral infections |
| Computational fluid dynamics study of nasal spray administration in 2 subjects showing 100x improvement in nasopharyngeal drug delivery using a new spray placement protocol. The study also found the optimal droplet size range for nasophar.. | ||
Dec 8 2021 |
et al., Journal of Evidence-Based Dental Practice, doi:10.1016/j.jebdp.2022.101777 (date from preprint) | Use of mouthwash and dentifrice containing antimicrobial phthalocyanine derivative for the reduction of clinical symptoms of COVID-19: A randomized triple-blinded clinical trial |
| 29% improved recovery (p=0.02). RCT 500 patients in Brazil, showing improved recovery with a phthalocyanine derivative mouthwash and toothpaste. Toothbrushing for 2 minutes, three times per day, and gargling/rising (5ml) for one minute, three times a day, for 7 days. | ||
Nov 15 2021 |
et al., German Medical Science GMS Publishing House, doi:10.3205/dgkh000426 (date from preprint) | Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial |
| 54% fewer cases (p=0.08). Comparison of two similar communities in Brazil, with one using a phthalocyanine derivative mouthwash, suggesting efficacy of the treatment in lowering COVID-19 cases. There was 54% lower risk of confirmed cases during the intervention in.. | ||
Oct 7 2021 |
et al., Scientific Reports, doi:10.1038/s41598-021-99013-5 | Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trial |
| 85% lower mortality (p=0.23), 92% lower ICU admission (p=0.02), and 54% lower hospitalization (p=0.03). RCT 41 patients in Brazil, 20 treated with a phthalocyanine derivative mouthwash, showing shorter hosptalization and lower ICU admission with treatment. One minute gargling/rinsing 5 times per day. | ||
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